1,154 research outputs found
Surface binding and internalization of platelet-derived growth factor in human fibroblasts.
Full text linkArterial smooth muscle cells in primary culture produce a platelet-derived growth factor-like protein.
Full text linkPlatelet-derived growth factor-B gene delivery sustains gingival fibroblast signal transduction
Full text linkPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65871/1/j.1600-0765.2008.01089.x.pd
Hydrocortisone-induced increase of PDGF β-receptor expression in a human malignant mesothelioma cell line
Get PDFThe effect of hydrocortisone (HC) on PDGF β-receptor expression was studied in the human malignant mesothelioma cell line Mero-14. HC was found to induce a time- and dose-dependent increase of PDGF β-receptor mRNA. Nuclear run off analysis revealed that HC induced increased transcription of the PDGF β-receptor gene. The expression of PDGF β-receptor protein was also elevated by HC as demonstrated with an immunoblotting assay. However, the number of PDGF-BB binding sites on the cell surface of Mero-14 remained unchanged upon HC treatment. These results suggest that steroid hormones can regulate PDGF receptor expression in vivo
PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly.
Full text linkCoexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF beta receptor in isolated pancreatic islet cells stimulates DNA synthesis.
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